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illuminated medical research institute portal

The Research Portal chart below is in the process of being created... However, some of it is ready today. ;-)

Name

Vitamins

TSH

TRH

Mitochondria

Hypothalamus

Estrogen

Research Results................

Turmeric Root (5% curcumin)

... C; E;

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Curcumin (Turmeric Root extract) is a at least 10 times more active as an antioxidant than Vitamin E & superoxide dismutase (key antioxidant).
Vitamin E is essential for fertility and reproduction. Vitamin E (Alpha-tocopherol) is plant-derived fat-soluble vitamin that exists in eight different isomers & 15 mg day during pregnancy. Vitamin E promotes the natural healing of: skin disease; cardiovascular disease; cancer (metabolic) disease; & cataracts ..... Rats also improve when the Vitamin E (antocianidin) is combine with 25% Bilberry extract.

The estrogen inhibitors including flavones from passionflower, chamomile, onion & garlic, curcumin, resveratol, & cruciferous indoles may counteract excess of estrogen in the body. Herbs known to be estrogen inhibitors may help provide a first defense against estrogen chemicals; such as: flavones from passionflower, chamomile, onion & garlic, curcumin, resveratol, & cruciferous indoles by counteracting the excess levels of estrogen within the body, when combined with anti-estrogenic foods.

Curcumin improves oestrogen dominance triggered by the environmental impact of chemicals & increase bile secretion.

Black Pepper

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Cinnamon Bark

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Kiwi Extract

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Sage

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Parsley

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Turmeric Root - extract (95% Curcumin)

... C; E;

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As a supplement, the standard dose of curcumin is one gram (1000 mg) per day. Unfortunately, curcumin has very poor bioavailability, that is, very little of what you ingest actually gets into your system.

A human trial with 25 subjects using up to 8000 mg of curcumin per day for 3 months found no toxicity from curcumin. Five other human trials using 1125–2500 mg of curcumin per day have also found it to be safe.

Reminder: 999 mg every 3 hours (slow release) is about 8000 mg daily.

8000 mg daily is an excessive amount for an adult, so one should work closely with multiple holistic medial professionals if an excessive amount is utilized to reduce the risks consuming too much, too soon.

999 mg to 2999 mg daily (slow release) seems to be more common.

Curcumin (Turmeric Root extract) is a at least 10 times more active as an antioxidant than Vitamin E & superoxide dismutase (key antioxidant).
Vitamin E is essential for fertility & reproduction. Vitamin E (Alpha-tocopherol) is plant-derived fat-soluble vitamin that exists in eight different isomers & 15 mg day during pregnancy. Vitamin E promotes the natural healing of: skin disease; cardiovascular disease; cancer (metabolic) disease; & cataracts ..... Rats also improve when the Vitamin E (antocianidin) is combine with 25% Bilberry extract.

The estrogen inhibitors including flavones from passionflower, chamomile, onion & garlic, curcumin, resveratol, & cruciferous indoles may counteract excess of estrogen in the body. Herbs known to be estrogen inhibitors may help provide a first defense against estrogen chemicals; such as: flavones from passionflower, chamomile, onion & garlic, curcumin, resveratol, & cruciferous indoles by counteracting the excess levels of estrogen within the body, when combined with anti-estrogenic foods.

Curcumin improves oestrogen dominance triggered by the environmental impact of chemicals & increase bile secretion.

Polygonum Cuspida Root - extract (trans-resveratrol)

... C; E;

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Mice that are 8-weeks of age, which consumed a very poor, high-fat, diet containing 0.4% resveratrol magically experienced a significant increase in energy expenditures & aerobic capacities by increasing the SIRT1- mediated PGC-1α activity & mitochondrial function in muscle & brown adipose tissue. Resveratrol improves mitochondrial function & protects against metabolic disease by activating SIRT1 & PGC-1 alpha.

Warning: Resveratrol's estrogenic effects could potentially increase the growth of breast cancer cells, making the remedy unsafe for women who have or are at risk of having estrogen-sensitive types of cancer (search), warns the University of Pittsburgh Medical Center.

The estrogen inhibitors including flavones from passionflower, chamomile, onion & garlic, curcumin, resveratol, & cruciferous indoles may counteract excess of estrogen in the body. Herbs known to be estrogen inhibitors may help provide a first defense against estrogen chemicals; such as: flavones from passionflower, chamomile, onion & garlic, curcumin, resveratol, & cruciferous indoles by counteracting the excess levels of estrogen within the body, when combined with anti-estrogenic foods.

Grape Seed - extract

... C; E;

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Grape Seed extract...

Enchinacea - extract

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Prunella vulgaris - extract

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Portulaca oleracea - extract

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Phycocyanin Blue Spirulina - extract

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B-complex vitamins, minerals, proteins, γ-linolenic acid, & super antioxidants: β-carotene, vitamin E; trace elements; & several unexplored bioactive compounds.

Coenzyme Q10

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1200 mg dose had less decline than those humans consuming less than 1200 mg of CoQ10; in terms of mental function; motor function; & ability to carry out activities of daily living.

Goldenseal Root - extract

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Goldenseal is a powerful immune stimulant.

Cayenne Pepper

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Cayenne contains capsaicin; which stimulates spinal nerves & activates the release of catecholamine in the adrenal gland (hormone known to increase metabolism)

Alfalfa - extract

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Bilberry - extract

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Pyrrolo-quinoline-quinone (PQQ)

... B;

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HUMAN DEADLY WARNING: Extremely high IV doses of PQQ (500 to 1,000mg/kg body weight) can cause death in rats [58, 59]

A study found that a week’s consumption of up to 0.3mg/kg PQQ (20 mg for a 70 kg male) is perfectly safe [57].

HUMAN DEADLY WARNING: A very small amount of PQQ can be deadly to a human. Only one-fourth of only one teaspoon daily alone is above 600 mg; which is not safe for human daily intake!

PQQ Human Half Life: 3 to 5 hours.

Slow Release Human: 1.999 mg of PQQ every 3 hours daily is estimated to equate out to about 15.99 mg daily total; in order to keep a consistent (slow release) for the estimated PQQ half life.

HUMAN WARNING & CONCLUSION: So, perhaps 6 mg every 3 hours of PQQ daily (about 47.9 mg daily total) would be too excessive for any adult & there could be damage done to the organs.

6mg daily or more PQQ per day are needed to effect changes, (such as antioxidant activities or C-reactive protein levels) & is naturally found in human milk (to support cellular growth) reproductive & growth-promoting factor when combined with a purified diet. PQQ is utilized in bacteria as a redox cycling cofactor & synthesized from a polypeptide precursor. Humans consume less than 2mg daily on average from foods.

A novel aspect of PQQ is its biosynthesis in bacteria from a ribosomally translated precursor peptide, PqqA. A glutamic acid & a tyrosine in PqqA are cross-linked by the radical SAM enzyme PqqE in the first step of PqqA modification. Efforts to understand PQQ biosynthesis have contributed to broad interest in radical SAM enzymes & their ability to modify proteins, & an analogous radical SAM enzyme-dependent pathway has since been found that produces the putative electron carrier mycofactocin, using a valine & a tyrosine from the precursor peptide MftA.
Intestinal bacteria such as Escherichia coli do not synthesize PQQ. PQQ naturally stems directly from soil & soil bacteria; thus being absorbed directly into the plant via the natural root absorption process.
PQQ is a compound found ubiquitously in plants, many simple & single cell eukaryotes such as yeast, & certain bacteria. Mice & rats with diets deficient in PQQ resulted in growth impairment, compromised immune response, abnormal reproductive performance, &. The major bacterial sources of PQQ are methylotrophic, rhizobium, & acetobacter bacteria.
(Search how to increase methylotrophic soil bacteria).
PQQ triggers the DNA reading protein CREB, which plays a key role in growth and gene expression & CREB stimulates the growth of new mitochondria & increases BDNF.
PQQ improves neurons in the brain; which is a possible mechanism for the improvement of memory function it appears to produce in aging humans & rats.


Warning: If one has hypothyroidism (under-active), ask multiple medical professionals about avoiding:

electricity; radiation; excessive iodine (more than 99 mcg daily - including Kelp); & Lemon Balm.

However, small amounts of Lemon Balm may or may not help with hyperthyroidism (over-active); however not hypothyroidism. This is due to the fact that Lemon Balm & excessive iodine (including Kelp) both help control an over-active thyroid via the TSH & TRH process, so naturally this would worsen a thyroid that is already damaged (under-active) from radioactive iodine (search) used in the medical field. "Both ashwagandha and gugulipids appear to boost thyroid function without influencing the release of the pituitary hormone TSH (thyroid-stimulating hormone), indicating that these herbs work directly on the thyroid gland and other body tissues."

(v.20190819)

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